Dedicated to transforming the care of people living with rare genetic diseases of obesity

OUR COMMUNITY

"When Tysen was three he was fifty pounds, when Mike was three he was eighty pounds."

Mike and Tysen, father and son living with MC4R Pathway Heterozygous Obesity

Joan, wife to Mike and mother to Tysen, both diagnosed with MC4R Pathway Heterozygous Obesity

 "Alström syndrome has a high impact on her weight...she constantly wants to eat and can't get enough."

Leigha, living with Alström syndrome

Breezy, mother of Leigha, diagnosed with Alström syndrome

 "I think the biggest thing to try to get people to understand is the constant hunger issue."

Solomon and Adalissa, siblings living with Bardet-Biedl syndrome

Olivia, Mother of Adalissa and Solomon, both diagnosed with Bardet Biedl syndrome

"When Tysen was three he was fifty pounds, when Mike was three he was eighty pounds."

Joan, wife to Mike and mother to Tysen, both diagnosed with MC4R Pathway Heterozygous Obesity

Mike and Tysen, father and son living with MC4R Pathway Heterozygous Obesity "Alström syndrome has a high impact on her weight...she constantly wants to eat and can't get enough."

Breezy, mother of Leigha, diagnosed with Alström syndrome

Leigha, living with Alström syndrome "I think the biggest thing to try to get people to understand is the constant hunger issue."

Olivia, Mother of Adalissa and Solomon, both diagnosed with Bardet Biedl syndrome

Solomon and Adalissa, siblings living with Bardet-Biedl syndrome

We’re focused on the melanocortin-4 receptor (MC4R) pathway, which is responsible for regulating weight and hunger.

By targeting the MC4R pathway, we aim to develop therapeutics
for rare genetic diseases of obesity, including:

Proopiomelanocortin
(POMC) Deficiency Obesity
Leptin Receptor (LEPR)
Deficiency Obesity
Bardet-Biedl
Syndrome (BBS)
Alström
Syndrome
POMC or LEPR
Heterozygous Deficiency Obesity
Smith-Magenis
Syndrome
SRC1 Deficiency
Obesity
MC4R Deficiency
Obesity
SH2B1 Deficiency
Obesity
Our Science

Our news

2021-10-14T16:01:00

Rhythm Pharmaceuticals Completes Submission of Type II Variation Application to the European Medicines Agency for IMCIVREE® (setmelanotide) for Bardet-Biedl and Alström Syndromes

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2021-10-14T08:00:00

Rhythm Pharmaceuticals Presents New Data on Experience of People Living with Rare Genetic Diseases of Obesity and Provides Updates on Uncovering Rare Obesity® Genetic Testing Program

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2021-09-22T10:30:00

Rhythm Pharmaceuticals Presents New Data from Phase 2 and 3 Trials Evaluating Setmelanotide in Multiple Rare Genetic Diseases of Obesity at the 59th Annual ESPE Meeting

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More News