Dedicated to transforming the care of people living with rare genetic diseases of obesity

"When Tysen was three he was fifty pounds, when Mike was three he was eighty pounds."

Joan, wife to Mike and mother to Tysen, both diagnosed with MC4R Pathway Heterozygous Obesity

Mike and Tysen, father and son living with MC4R Pathway Heterozygous Obesity
"Alström syndrome has a high impact on her weight...she constantly wants to eat and can't get enough."

Breezy, mother of Leigha, diagnosed with Alström syndrome

Leigha, living with Alström syndrome
"I think the biggest thing to try to get people to understand is the constant hunger issue."

Olivia, Mother of Adalissa and Solomon, both diagnosed with Bardet Biedl syndrome

Solomon and Adalissa, siblings living with Bardet-Biedl syndrome

We’re focused on the melanocortin-4 receptor (MC4R) pathway, which is responsible for regulating weight and hunger.


By targeting the MC4R pathway, we aim to develop therapeutics
for rare genetic diseases of obesity, including:

Proopiomelanocortin
(POMC) Deficiency Obesity
Leptin Receptor (LEPR)
Deficiency Obesity
Bardet-Biedl
Syndrome (BBS)
Alström
Syndrome
POMC or LEPR
Heterozygous Deficiency Obesity
Smith-Magenis
Syndrome
SRC1 Deficiency
Obesity
MC4R Deficiency
Obesity
SH2B1 Deficiency
Obesity

Our news

2021-07-29T08:00:00

Rhythm Pharmaceuticals Announces Senior Leadership Additions

2021-07-28T16:01:00

Rhythm Pharmaceuticals Announces Collaborative Research Agreement with Clinical Registry Investigating Bardet-Biedl Syndrome

2021-07-27T08:00:00

Rhythm Pharmaceuticals to Report Second Quarter 2021 Financial Results on Tuesday, August 3, 2021